Cognitive dysfunctions in older adults with depression

Authors

DOI:

https://doi.org/10.22201/cuaieed.16076079e.2021.22.2.2

Keywords:

executive function, depression, cognition, therapy

Abstract

Depression is one of the most prevalent mental disorders worldwide. The daily functionality of those who suffer from it is affected due to negative symptoms, social isolation, and decreased psychomotor activity. If it occurs in an elderly person, it can be incapacitating when, in addition to depressive symptoms, it is accompanied by cognitive disorders. The usual treatment for depressive disorders is Selective Serotonin Reuptake Inhibitors (ssris), however, in elderly adults with executive dysfunction, this treatment may be less effective, thus other psychotherapeutic drugs and methods should be analyzed to improve people’s quality of life. Therefore, the objective of this article is to provide a description of the cognitive dysfunctions present in older adults with depression, as well as some guidelines for their treatment.

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Author Biographies

Jorge Dario Lopez Sanchez, Universidad Veracruzana

Maestro en Neuroetología, Especialista en Métodos Estadísticos, Licenciado en Psicología. Todos los grados fueron obtenidos en la Universidad Veracruzana. Línea de investigación: Neurofisiología y neuropsicología del envejecimiento.

Actualmente es estudiante del Doctorado en Neuroetología por el Instituto de Neuroetología de la Universidad Veracruzana. Docente de la Facultad de Psicología Región Xalapa, y colaborador del Laboratorio de Psicobiología, donde desarrolla investigaciones sobre los procesos neurofisiológicos y neuropsicológicos del envejecimiento, así como sobre los procesos cognitivos de adultos.

Dora Elizabeth Granados Ramos, Universidad Veracruzana

Doctora en Neurociencias por la Universidad de Guadalajara 2003, Maestra en Rehabilitación Neurológica, UAM Xochimilco, 1993, Licenciada en Educación Especial, Escuela Normal de Especialización, 1989. Línea de investigación: Neurodesarrollo del lenguaje y pensamiento.

Actualmente es Profesora Investigadora Titular C, adscrita al Laboratorio de Psicobiología de la Facultad de Psicología Región Xalapa, donde desarrolla investigaciones sobre la evaluación neuropsicológica de pacientes con dificultades de aprendizaje. Es miembro del Sistema Nacional de Investigadores Nivel 1.

References

Alexopoulos, G. S. (2001). The depression-executive dysfunction syndrome of late life: a specific target for D3 agonists? Am J Geriatr Psychiatry, 9(1), 22-29. doi: https://www.doi.org/10.1097/00019442-200102000-00004.

American Psychological Association (apa). (2020). Depression. American Psychological Association. https://www.apa.org/topics/depression/.

Baune, B., Malhi, G., Morris, G., Outhred, T., Hamilton, A., Das, P., Basset, D., Berk, M., Boyce, P., Lyndon, B., Mulder, R., Parker, G. y Singh, A. (2018). Cognition in depression: Can we THINC-it better? Journal of Affective Disorders, 225, 559-562. doi: https://www.doi.org/10.1016/j.jad.2017.08.080.

Bogner, H. R., Bruce, M. L., Reynolds iii, C. F., Mulsant, B. H., Cary, M. S., Morales, K. y Alexopoulos, G. S. (2007). The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the prospect study. Int J Geriatr Psychiatry, 22, 922-929. doi: https://doi.org/10.1002/gps.1767.

Brown, P. J., Sneed, J. R., Rutherford, B. R., Devanand, D. P., y Roose, S. P. (2014). The nuances of cognition and depression in older adults: the need for a comprehensive assessment. Int J Geriatr Psychiatry, 29(5), 506-514. doi: https://doi.org/10.1002/gps.4033.

Crocco, E. A, Castro, K. C. y Loewenstein, D. A. (2010). How Late-Life Depression Affects Cognition: Neural Mechanisms. Current Psychiatry Reports, 12, 34–38. doi: https://doi.org/10.1007/s11920-009-0081-2.

Donovan, N. J., Wu, Q., Rents, D. M., Sperling, R. A., Marshall, G. A. y Glymour, M. M. (2017). Loneliness, depression and cognitive function in older U.S. Adults. Int J Geriatr Psychiatry, 32 (5), 564-573. doi: https://doi.org/10.1002/gps.4495.

Fischer, C., Schweizer, T. A., Atkins, J. H., Bozanovic, R., Norris, M., Herrmann, N., Nisenbaum, R. y Rourke, S. B. (2008). Neurocognitive profiles in older adults with and without major depression. Int J Geriatr Psychiatry, 23(8), 851-856. doi: https://doi.org/10.1002/gps.1994.

Hiemke, C. y Härtter, S. (2000). Pharmacokinetics of selective serotonine reuptake inhibitors. Pharmacology & Therapeutics, 85(1), 11-28. doi: https://doi.org/10.1016/S0163-7258(99)00048-0.

McLennan, S. y Mathias, J. (2010). The depressión-executive dysfunction (ded) syndrome and response to antidepressants: a meta-analytic review. Int J Geriatr Psychiatry, 25(10), 933-944. doi: https://doi.org/10.1002/gps.2431.

Pantzar, A., Atti, A. R., Fratiglioni, L., Fastbom, J., Bäckman, L., y Laukka, E. J. (2017). Cognitive performance in unipolar old-age depression: a longitudinal study. Int J Geriatr Psychiatry, 32(6), 675-684. doi: https://doi.org/10.1002/gps.4510.

Ritchie, H. y Roser, M. (2018, January 20). Mental Health. Our World in Data. https://ourworldindata.org/mental-health.

Thomas, A. J. y O’Brien, J. T. (2008). Depression and cognition in older adults. Current Opinion in Psychiatry, 21(1), 8-13. doi: https://doi.org/10.1097/YCO.0b013e3282f2139b.

Weisenbach, S. L., Boore, L. A. y Kales, H. C. (2012). Depression and Cognitive Impairment in Older Adults. Current Psychiatry Reports, 14, 280-288. doi: https://doi.org/10.1007/s11920-012-0278-7.

World Health Organization: [who]. (2017, January 3). Depression and Other Common Mental Disorders. https://www.who.int/publications-detail/depression-global-health-estimates.

World Health Organization [who]. (2019, December 19). Mental Health. https://www.who.int/health-topics/mental-health.

Published

2021-03-01