A weapon to acquire resistance: Information exchange in bacteria
DOI:
https://doi.org/10.22201/ceide.16076079e.2025.26.5.6Keywords:
antibiotic resistance, resistant bacteria, horizontal gene transfer, antimicrobials, responsible antibiotic useAbstract
Although we often think of bacteria as enemies, most of them are actually our allies: they live with us and help keep us healthy. However, some have learned to resist antibiotics, posing a serious threat to global health. This article explains how bacteria share genetic information through a process known as horizontal gene transfer, which allows them to become stronger and adapt quickly. Through clear examples and curious comparisons —such as “bacterial sex” or “DNA eating”— it shows how these microorganisms learn and defend themselves, and why the responsible use of antibiotics is key to curbing antimicrobial resistance.
References
Álvarez, J., Fernández Real, J. M., Guarner, F., Gueimonde, M., Rodríguez, J. M., Saenz de Pipaon, M., y Sanz, Y. (2021, 1 de agosto). Microbiota intestinal y salud. Gastroenterología y Hepatología, 44(7), 519-535. https://doi.org/10.1016/j.gastrohep.2021.01.009
Ambur, O. H., Engelstädter, J., Johnsen, P. J., Miller, E. L., y Rozen, D. E. (2016, 16 de octubre). Steady at the wheel: conservative sex and the benefits of bacterial transformation. Philosophical Transaction of the Royal Society B: Biological Sciences, 371. https://doi.org/10.1098/rstb.2015.0528
Cabezón, E., Ripoll-Rozada, J., Peña, A., De la Cruz, F., y Arechaga, I. (2015). Towards an integrated model of bacterial conjugation. fems Microbiology Reviews, 39(1), 81-95. https://doi.org/10.1111/1574-6976.12085
Chávez-Jacobo, V. M. (2020, 19 de febrero). La batalla contra las superbacterias: No más antimicrobianos, no hay eskape. tip Revista especializada en Ciencias Químico-Biológicas, 23. https://doi.org/10.22201/fesz.23958723e.2020.0.202
Huang, M., Liu, M., Huang, L., Wang, M., Jia, R., Zhu, D., Chen, S., Zhao, X., Zhang, S., Gao, Q., Zhang, L., y Cheng, A. (2021, noviembre). The activation and limitation of the bacterial natural transformation system: The function in genome evolution and stability. Microbiological Research, 252. https://doi.org/10.1016/j.micres.2021.126856
Lee, A. R., Park, S. B., Kim, S. W., Jung, J. W., Chun, J. H., Kim, J., Kim, Y. R., Lazarte, J. M. S., Jang, H. B., Thompson, K. D., Jung, M., Ha, M. W., y Jung, T. S. (2022, 1 de abril). Membrane vesicles from antibiotic-resistant Staphylococcus aureus transfer antibiotic-resistance to antibiotic-susceptible Escherichia coli. Journal of Applied Microbiology. 132(4), 2746-2759. https://doi.org/10.1111/jam.15449
Llosa, M., Gomis-Rüth, F. X., Coll, M., y De la Cruz, F. (2002, 28 de junio) Bacterial conjugation: a two-step mechanism for dna transport. Molecular Microbiology, 45(1),1-8. https://doi.org/10.1046/j.1365-2958.2002.03014.x
Organización Mundial de la Salud (oms). (2021, 17 de noviembre). Resistencia a los antimicrobianos. https://tinyurl.com/4ny7wz7p
Snyder, L., Peters, J., Henkin, T. y Champness, W. (2013). Molecular Genetics of Bacteria (4.a ed.). asm Press.
Toyofuku, M., Nomura, N., y Eberl, L. (2019). Types and origins of bacterial membrane vesicles. Nature Reviews Microbiology, 17(1), 13-24. https://doi.org/10.1038/s41579-018-0112-2
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