A weapon to acquire resistance: Information exchange in bacteria

Authors

DOI:

https://doi.org/10.22201/ceide.16076079e.2025.26.5.6

Keywords:

antibiotic resistance, resistant bacteria, horizontal gene transfer, antimicrobials, responsible antibiotic use

Abstract

Although we often think of bacteria as enemies, most of them are actually our allies: they live with us and help keep us healthy. However, some have learned to resist antibiotics, posing a serious threat to global health. This article explains how bacteria share genetic information through a process known as horizontal gene transfer, which allows them to become stronger and adapt quickly. Through clear examples and curious comparisons —such as “bacterial sex” or “DNA eating”— it shows how these microorganisms learn and defend themselves, and why the responsible use of antibiotics is key to curbing antimicrobial resistance.

References

Álvarez, J., Fernández Real, J. M., Guarner, F., Gueimonde, M., Rodríguez, J. M., Saenz de Pipaon, M., y Sanz, Y. (2021, 1 de agosto). Microbiota intestinal y salud. Gastroenterología y Hepatología, 44(7), 519-535. https://doi.org/10.1016/j.gastrohep.2021.01.009

Ambur, O. H., Engelstädter, J., Johnsen, P. J., Miller, E. L., y Rozen, D. E. (2016, 16 de octubre). Steady at the wheel: conservative sex and the benefits of bacterial transformation. Philosophical Transaction of the Royal Society B: Biological Sciences, 371. https://doi.org/10.1098/rstb.2015.0528

Cabezón, E., Ripoll-Rozada, J., Peña, A., De la Cruz, F., y Arechaga, I. (2015). Towards an integrated model of bacterial conjugation. fems Microbiology Reviews, 39(1), 81-95. https://doi.org/10.1111/1574-6976.12085

Chávez-Jacobo, V. M. (2020, 19 de febrero). La batalla contra las superbacterias: No más antimicrobianos, no hay eskape. tip Revista especializada en Ciencias Químico-Biológicas, 23. https://doi.org/10.22201/fesz.23958723e.2020.0.202

Huang, M., Liu, M., Huang, L., Wang, M., Jia, R., Zhu, D., Chen, S., Zhao, X., Zhang, S., Gao, Q., Zhang, L., y Cheng, A. (2021, noviembre). The activation and limitation of the bacterial natural transformation system: The function in genome evolution and stability. Microbiological Research, 252. https://doi.org/10.1016/j.micres.2021.126856

Lee, A. R., Park, S. B., Kim, S. W., Jung, J. W., Chun, J. H., Kim, J., Kim, Y. R., Lazarte, J. M. S., Jang, H. B., Thompson, K. D., Jung, M., Ha, M. W., y Jung, T. S. (2022, 1 de abril). Membrane vesicles from antibiotic-resistant Staphylococcus aureus transfer antibiotic-resistance to antibiotic-susceptible Escherichia coli. Journal of Applied Microbiology. 132(4), 2746-2759. https://doi.org/10.1111/jam.15449

Llosa, M., Gomis-Rüth, F. X., Coll, M., y De la Cruz, F. (2002, 28 de junio) Bacterial conjugation: a two-step mechanism for dna transport. Molecular Microbiology, 45(1),1-8. https://doi.org/10.1046/j.1365-2958.2002.03014.x

Organización Mundial de la Salud (oms). (2021, 17 de noviembre). Resistencia a los antimicrobianos. https://tinyurl.com/4ny7wz7p

Snyder, L., Peters, J., Henkin, T. y Champness, W. (2013). Molecular Genetics of Bacteria (4.a ed.). asm Press.

Toyofuku, M., Nomura, N., y Eberl, L. (2019). Types and origins of bacterial membrane vesicles. Nature Reviews Microbiology, 17(1), 13-24. https://doi.org/10.1038/s41579-018-0112-2

Published

2025-11-05