Pollution and epigenetics: can our experiences affect the health of our children?

Authors

  • Miguel Chin-Chan Universidad Autónoma de Campeche
  • María Guadalupe Maldonado-Velázquez Universidad Autónoma de Campeche

Keywords:

epigenetics, pollution, transgenerational, inheritance, genetics

Abstract

Our gene expression is regulated by chemical tags attached to DNA which indicates when genes should be switched on or off. Any alterations in the pattern of these chemical tags, especially during early life stages, such as pregnancy or neonatal life, can affect gene expression immediately or even decades later. Our experiences such as lifestyle, diet and pollution can modify the pattern of chemical marks and the most worrying thing is that the harmful effects can inherit across generations, according to some studies. Thus, it would be precise to wonder ourselves whether our experiences such as the food we eat, the kind of life style we have and the environment where we live will affect the health of our children.

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Author Biographies

Miguel Chin-Chan, Universidad Autónoma de Campeche

Universidad Autónoma de Campeche, Facultad de Ciencias Químico-Biológicas. Es Químico Farmacéutico Biólogo por la Universidad Autónoma de Campeche (UACam), maestro y doctor en Ciencias en Toxicología por el Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN). Es profesor-investigador de la Facultad de Ciencias Químico Biológicas de laUACam. Actualmente realiza una estancia posdoctoral en el Leibniz Institute on Aging, Alemania. Ha publicado en revistas de impacto internacional y ha asistido a congresos nacionales e internacionales en el campo de Toxicología y Neurociencias.

María Guadalupe Maldonado-Velázquez, Universidad Autónoma de Campeche

Universidad Autónoma de Campeche, Facultad de Ciencias Químico-Biológicas (FCQB). Es Químico Farmacéutico Biólogo por la UACam, realizó estudios de maestría en Ciencias en Microbiología en la FCQB de la UACam. Es profesor-investigador de la FCQB,UACam. Vocal Regional de la Conferencia Iberoamericana de Facultades de Farmacia. Química Clínica certificada por la Federación Nacional de Química Clínica. Ha publicado en revistas de impacto internacional y ha asistido a congresos nacionales e internacionales en el campo de Enfermedades infecciosas y Farmacia.

References

Anway, M. D., A. S. Cupp, M. Uzumcu y M. K. Skinner (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 308:1466-1469. DOI: https://doi.org/10.1126/science.1108190

Anway, M. D. y M. K. Skinner (2008). Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease. Reprod Biomed Online. 16: 23-25. https://doi.org/10.1016/S1472-6483(10)60553-6

Ho, S. M., A. Johnson, P. Tarapore, V. Janakiram, X. Zhang y Y. K. Leung (2012). Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 53: 289-305. DOI: https://doi.org/10.1093/ilar.53.3-4.289

Kaneda, M. (2011). Genomic imprinting in mammals-epigenetic parental memories. Differentiation. 82: 51-56. DOI: https://doi.org/10.1016/j.diff.2011.05.004

Kelishadi, R., P. Poursafa y F. Jamshidi (2013). Role of environmental chemicals in obesity: a systematic review on the current evidence. J Environ Public Health. 2013: 896789. DOI: http://dx.doi.org/10.1155/2013/896789.

Kiefer, J. C. (2007). Epigenetics in development. Developmental Dynamics. 236: 1144-1156. DOI: https://doi.org/10.1002/dvdy.21094.

Lucas, A., M. S. Fewtrell y T. J. Cole (1999). Fetal origins of adult disease-the hypothesis revisited. BMJ. 319: 245-249. DOI: https://doi.org/10.1136/bmj.319.7204.245.

OMS (2006). La exposición a riesgos ambientales provoca casi una cuarta parte de las enfermedades. Centro de prensa. http://www.who.int/mediacentre/news/releases/2006/pr32/es/.

Reed, C. E. y S. E. Fenton (2013). Exposure to diethylstilbestrol during sensitive life stages: a legacy of heritable health effects. Birth Defects Res C. 99: 134-146. DOI: http://doi.org/10.1002/bdrc.21035.

Skinner, M. K. (2008). What is an epigenetic transgenerational phenotype? F3 or F2. Reproductive Toxicology. 25: 2-6. DOI: http://doi.org/10.1016/j.reprotox.2007.09.00.

Skinner, M. K. (2011). Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability. Epigenetics. 6(7), 838-842. DOI: http://doi.org/10.4161/epi.6.7.16537.

Skinner, M. K. (2014). Endocrine disruptor induction of epigenetic transgenerational inheritance of disease. Mol Cell Endocrinol. 398: 4-12. DOI: https://doi.org/10.1016/j.mce.2014.07.019.

Skinner, M. K., M. Manikkam y C. Guerrero-Bosagna (2010). Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab. 21: 214-222. DOI: https://doi.org/10.1016/j.mce.2014.07.019.

Skinner, M. K., M. Manikkam, R. Tracey, C. Guerrero-Bosagna, M. Haque y E. E. Nilsson (2013). Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotesepigenetic transgenerational inheritance of obesity. BMC Medicine. 11: 228. DOI: https://doi.org/10.1186/1741-7015-11-228.

University of Utha (s.f) Insights From Identical Twins. Learn genetics. Genetic Science Learning Center. University of Utha. Recuperado de http://learn.genetics.utah.edu/content/epigenetics/twins/.

Veenendaal, M. V., R. C. Painter, S. R. de Rooij, P. M. Bossuyt, J. A. van der Post, P. D. Gluckman, M. A. Hanson y T. J. Roseboom (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG 120: 548-553. DOI: https://doi.org/10.1111/1471-0528.12136.

Wolstenholme, J. T., J. A. Goldsby y E. F. Rissman (2013). Transgenerational effects of prenatal bisphenol A on social recognition. Hormones and Behavior 64: 833-839. DOI: https://doi.org/10.1016/j.yhbeh.2013.09.007.

Wu, J., M. R. Basha, B. Brock, D. P. Cox, F. Cardozo-Pelaez, C. A. McPherson, J. Harry, D. C. Rice, B. Maloney, D. Chen, D. K. Lahiri y N. H. Zawia (2008). Alzheimer’s disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. Journal of Neuroscience. 28:3-9. DOI: https://doi.org/10.1523/JNEUROSCI.4405-07.2008.

Published

2018-01-01

Issue

Vol. 19 No. 1 (2018): Innovar o no innovar, ¿he ahí el dilema?

Section

Varietas

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