Bacteriophages, the bacteria-eating viruses: the story of two scientific minds
DOI:
https://doi.org/10.22201/cuaieed.16076079e.2021.22.5.9Keywords:
discovery, bacteriophages, Twort, d’HerelleAbstract
The discovery of bacteriophages (bacteria-eating viruses) is under discussion, some authors consider Felix d’Herelle as the only official discoverer of bacteriophages because he was able to prove, in 1917, that those entities, different from all known at the time, were responsible for lytic activity. In contrast, other authors propose Frederick W. Twort as the true discoverer, as, in 1915, he reported a lytic activity, even though he could not determine its origin. This article recounts the observations, proposals, and ideas of two individuals who were pillars in the discovery of bacteriophages, now being considered as tools to effectively combat deadly diseases of bacterial origin.
References
Adenosina. (2009). [Artistic rendering of a T4 bacteriophage]. Wikimedia Commons. https://en.wikipedia.org/wiki/File:PhageExterior.svg.
d’Herelle, F. (1917). On an invisible microbe antagonistic toward dysentery bacilli: brief note by M. F. d’Herelle, presented by Mr. Roux. Comptes Rendus Academie des Sciences, 1917;165:373-375. Bacteriophage. (2011)1, 3-5. http://dx.doi.org/10.4161/bact.1.1.14941.
d’Herelle, F. (1922). The bacteriophage: Its role in immunity. Biodiversity Heritage Library. https://www.biodiversitylibrary.org/bibliography/31194.
Duckworth, D. H. (1976). Who Discovered Bacteriophage? Bacteriology Reviews, 40(4), 793–802.
Dy, R. L., Rigano, L. A. y Fineran, P. C. (2018). Phage-based biocontrol strategies and their application in agriculture and aquaculture. Biochemical Society Trasactions, 46(6), 1605–1613. https://doi.org/10.1042/BST20180178.
Hankin, M. E. (1896). L’action bactéricide des eaux de la Jumna et du Gange sur le microbe du choléra. Annales de l’Institut Pasteur, 10(9), 511 – 523.
Jamal, M., Bukhari, S. M. A. U. S., Andleeb, S., Ali, M., Raza, S., Nawaz, M. A., Hussain, T., Rahman, S. U. y Shah, S. S. A. (2019). Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields. Journal of Basic Microbiology, 59(2), 123-133. https://doi.org/10.1002/jobm.201800412.
Keen, E. C. (2015). A century of phage research: Bacteriophages and the shaping of modern biology. Bioessays, 37(1), 6–9. https://doi.org/10.1002/bies.201400152.
Kropinski, A. M. (2006). Phage therapy – Everything old is new again. Canadian Journal of Infectious Disease and Medical Microbiology, 17(5), 297–306. https://doi.org/10.1155/2006/329465.
Kutateladze, M. (2015). Experience of the Eliava Institute in bacteriophage therapy. Virologica Sinica, 30, 80–81. http://dx.doi.org/10.1007/s12250-014-3557-0.
Kutateladze, M. y Adamia, R. (2010). Bacteriophages as potential new therapeutics to replace or supplement antibiotics. Trends in Biotechnology, 28(12), 591–595. http://dx.doi.org/10.1016/j.tibtech.2010.08.001.
Lobocka, M. y Szybalski, W. (Eds.). (2012). Advances in Virus Research (vol. 83). Academic Press.
Lozano, S. (2007). Félix d’Herelle. Aportes a la bibliografía de un pasteuriano en México (1904-1911). Revista Electrónica Latinoamericana de Estudios Sociales, Históricos y Culturales de la Ciencia y la Tecnología, 1. https://cutt.ly/rWYGMvy.
Salmond, G. P. y Fineran, P. C. (2015). A century of the phage: past, present and future. Nature Reviews Microbiology, 13, 777–786. https://doi.org/10.1038/nrmicro3564.
Service photo Institut Pasteur – Photothèque. (1905). Portrait de Félix d’Hérelle, vers 1905 [fotografía]. Wikimedia Commons. https://en.wikipedia.org/wiki/File:F%C3%A9lix_d%27H%C3%A9relle.jpg.
Sulakvelidze, A., Alavidze, Z. y Morris, J. R. (2001). Bacteriophage Therapy. Antimicrobial Agents and Chemotherapy, 45(3), 649–659. https://doi.org/10.1128/AAC.45.3.649-659.2001.
Summers, W. C. (2016). Félix Hubert d’Herelle (1873-1949): History of a scientific mind. Bacteriophage, 6(4), e1270090. https://doi.org/10.1080/21597081.2016.1270090.
Talavera-González, J. M., Talavera-Rojas, M., Soriano-Vargas, E., Vazquez-Navarrete, J. y Salgado-Miranda, C. (2021). In vitro transduction of antimicrobial resistance genes into Escherichia coli isolates from backyard poultry in Mexico. Canadian Journal of Microbiology, 67(5), 415-425. https://doi.org/10.1139/cjm-2020-0280.
Thomas, G. (2014). Frederick William Twort: not just bacteriophage. Microbiology today, 41(2), 70–73. https://cutt.ly/XWYLMs9.
Twort, F. W. (1915) An investigation on the nature of ultra-microscopic viruses. The Lancet, 186(4814), 1241–1243. http://dx.doi.org/10.1016/S0140-6736(01)20383-3.
Twort, F. W. (1921). The discovery of the “Bacteriophage”. The Lancet, 205(5303), 845. http://dx.doi.org/10.1016/S0140-6736(01)22250-8.
Twort, F. W. (1925) The ultra-microscopic viruses. The Lancet, 198(5111), 204. http://dx.doi.org/10.1016/S0140-6736(01)32229-8.
Wittebole, X., De Roock, S. y Opal, S. M. (2014). A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence, 5(1), 226–235. http://dx.doi.org/10.4161/viru.25991.
Published
Issue
Section
License
Copyright (c) 2022 Revista Digital Universitaria

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Revista Digital Universitaria es editada por la Universidad Nacional Autónoma de México se distribuye bajo una Licencia Creative Commons Atribución-NoComercial 4.0 Internacional. Basada en una obra en http://revista.unam.mx/.