The frontier of the mind
DOI:
https://doi.org/10.22201/ceide.16076079e.2025.26.5.1Keywords:
cerebral territory, blood-brain barrier, cerebral edema, endothelial cellsAbstract
This article provides an accessible overview of the structure and function of the blood–brain barrier, emphasizing that although it acts as a defensive shield protecting the brain, it is not static; on the contrary, it is highly dynamic and capable of regulating the exchange of molecules between the bloodstream and the brain. By drawing parallels between the remarkable similarities of natural barriers in the human body and the physical frontiers used by humanity to delimit or safeguard territories, the article highlights the crucial role of the blood–brain barrier in ensuring proper brain function. It also explores how damage to this defensive structure contributes to the development of neuropathologies.
References
Acarón Ledesma, H., Li, X., Carvalho-de-Souza, J. L., Wei, W., Bezanilla, F., y Tian, B. (2019). An atlas of nano-enabled neural interfaces. Nature nanotechnology, 14(7), 645-657. https://doi.org/10.1038/s41565-019-0487-x
Alquisiras-Burgos, I., Ortiz-Plata, A., Franco-Pérez, J., Millán, A., y Aguilera, P. (2020, agosto). Resveratrol reduces cerebral edema through inhibition of de novo sur1 expression induced after focal ischemia. Experimental neurology, 330. https://doi.org/10.1016/j.expneurol.2020.113353
Arrizabalaga, M. (2017, 31 de octubre). Todos los Santos de auténtico terror en la Historia. abc Historia. https://tinyurl.com/bdz8t58d
Azarfar, A., Calcini, N., Huang, C., Zeldenrust, F., y Celikel, T. (2018, noviembre). Neural coding: A single neuron’s perspective. Neuroscience and Biobehavioral Reviews, 94, 238-247. https://doi.org/10.1016/j.neubiorev.2018.09.007
Begley, D. J. (2006). The significance of the blood-brain barrier for Gaucher disease and other lysosomal storage diseases. En A. H. Futerman y y A. Zimran (Eds.). Gaucher Disease (pp. 397-421). crc Press. https://tinyurl.com/2m9d2nfh
Blanchette, M., y Daneman, R. (2015, noviembre). Formation and maintenance of the bbb. Mechanisms of Development, 138(Parte 1), 8-16. https://doi.org/10.1016/j.mod.2015.07.007
Daneman, R., y Prat, A. (2015). The blood-brain barrier. Cold Spring Harbor Perspectives in Biology, 7(1). https://doi.org/10.1101/cshperspect.a020412
Eng, M. E., Imperio, G. E., Bloise, E., y Matthews, S. G. (2022, 11 de julio). atp-binding cassette (abc) drug transporters in the developing blood-brain barrier: role in fetal brain protection. Cellular and molecular life sciences, 79(415). https://doi.org/10.1007/s00018-022-04432-w
Gu, Y., Zhou, C., Piao, Z., Yuan, H., Jiang, H., Wei, H., Zhou, Y., Nan, G., y Ji, X. (2022, 28 de agosto). Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.988283
Hladky, S. B., y Barrand, M. A. (2018, 19 de octubre). Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier. Fluids and barriers of the cns, 15(30). https://doi.org/10.1186/s12987-018-0113-6
Infobae. (2022, 30 julio). Por qué se secó el lago de Texcoco. Infobae. https://www.infobae.com/america/mexico/2022/07/30/por-que-se-seco-el-lago-de-texcoco/
Izazola, H. (2001, 1 de mayo). Agua y sustentabilidad en la Ciudad de México. Estudios Demográficos Y Urbanos, 16(2), 285-320. https://doi.org/10.24201/edu.v16i2.1121
Kadry, H., Noorani, B., y Cucullo, L. (2020, 18 de noviembre). A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids and barriers of the cns, 17(69). https://doi.org/10.1186/s12987-020-00230-3
Löscher, W., y Potschka, H. (2005, enero). Blood-brain barrier active efflux transporters: atp-binding cassette gene family. NeuroRx: The journal of the American Society for Experimental NeuroTherapeutics, 2(1), 86-98. https://doi.org/10.1602/neurorx.2.1.86
Lovinger D. M. (2008). Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. Alcohol Research and Health, 31(3), 196-214. https://pmc.ncbi.nlm.nih.gov/articles/PMC3860493/
Lu, C. W., Lin, T. Y., Yeh, K. C., Hsieh, P. W., Chiu, K. M., Lee, M. Y., y Wang, S. J. (2025, mayo). Reduction in presynaptic glutamate release and the prevention of glutamate excitotoxicity by lupeol in rats. Neurochemistry international, 185. https://doi.org/10.1016/j.neuint.2025.105951
Pelegero, B. (2023, 4 de octubre). La Gran Muralla china: mayor obra de ingeniería del mundo. National Geographic Historia. https://historia.nationalgeographic.com.es/a/gran-muralla-china-mayor-obra-ingenieria-mundo_8272
Profaci, C. P., Munji, R. N., Pulido, R. S., y Daneman, R. (2020,25 de marzo). The blood-brain barrier in health and disease: Important unanswered questions. The Journal of experimental medicine, 217(4). https://doi.org/10.1084/jem.20190062
Stokum, J. A., Kwon, M. S., Woo, S. K., Tsymbalyuk, O., Vennekens, R., Gerzanich, V., y Simard, J. M. (2018). sur1-trpm4 and aqp4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. Glia, 66(1), 108–125. https://doi.org/10.1002/glia.23231
Stokum, J.A., Gerzanich, V., y Simard, J.M. (2015). Molecular pathophysiology of cerebral edema. Journal of Cerebral Blood Flow and Metabolism, 36, 513 - 538.
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., y Zlokovic, B. V. (2019, enero). Blood-Brain Barrier: From physiology to disease and back. Physiological Reviews, 99(1), 21-78. https://doi.org/10.1152/physrev.00050.2017
Thorén, M., Azevedo, E., Dawson, J., Egido, J. A., Falcou, A., Ford, G. A., Holmin, S., Mikulik, R., Ollikainen, J., Wahlgren, N., y Ahmed, N. (2017). Predictors for cerebral edema in acute ischemic stroke treated with intravenous thrombolysis. Stroke, 48(9), 2464-2471. https://doi.org/10.1161/STROKEAHA.117.018223
Tournissac, M., Chaigneau, E., Pfister, S., Aydin, A. K., Goulam Houssen, Y., O’Herron, P., Filosa, J., Collot, M., Joutel, A., y Charpak, S. (2024, 2 de septiembre). Neurovascular coupling and co2 interrogate distinct vascular regulations. Nature Communications, 15(17635). https://doi.org/10.1038/s41467-024-49698-9
Wijaya, J., Fukuda, Y., y Schuetz, J. D. (2017, 27 de noviembre). Obstacles to Brain Tumor Therapy: Key abc Transporters. International Journal of Molecular Sciences, 18(12). https://doi.org/10.3390/ijms18122544
Zhou, Y., y Danbolt, N. C. (2014, 1 de marzo). Glutamate as a neurotransmitter in the healthy brain. Journal of Neural Transmission, 121(8), 799-817. https://doi.org/10.1007/s00702-014-1180-8
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