A new path to HIV elimination
Keywords:
HIV, CD4 lymphocytes, AIDS, reservoirsAbstract
A group of French researchers have identified a marker that makes possible to differentiate "inactive" HIV-infected cells from healthy cells. This discovery will allow the isolation and analysis of reservoir cells. A reservoir refers to CD4 lymphocytes or other resting cells (located in blood or other tissues), infected with HIV but not actively producing HIV. They are established during the earliest stage of infection and, although antiretroviral therapy can reduce HIV concentration in the blood to an undetectable level, latent (resting) virus reservoirs survive treatment. When a cell with latent infection is reactivated (for example, upon discontinuation of treatment), the reservoirs begin to produce the virus again. For that reason, antiretroviral treatment can not cure HIV infection.
References
Aguilar Camín, Héctor, “Reencuentro” [en línea], Nexos, 1 abril 2009, <http://www.nexos.com.mx/?p=13044> [Consulta: 20 de marzo 2017].
_____, Adiós a los Padres, México, Random House, 2014, pp. 344.
Communiqué de Presse National, “Découverte d’un marqueur du réservoir du VIH: une nouvelle piste pour éliminer le virus”, 14 de marzo 2017, INSERM, <http://www2.cnrs.fr/sites/communique/fichier/cp_reservoir_vih_ok.pdf> [Consulta: 20 de marzo 2017].
Descours, Benjamin, Gaël Petitjean, José-Luis López-Zaragoza, Timothée Bruel, Raoul Raffel, Christina Psomas, Jacques Reynes, Christine Lacabaratz, Yves Levy, Olivier Schwartz, Jean Daniel Lelievre y Monsef Benkirane, “CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses” [en línea], Nature, 15 de marzo 2017, Vol. 543, pp. 564-567, doi:101038/nature21710, <http://www.nature.com/nature/journal/v543/n7646/full/nature21710.html> [Consulta: 20 de marzo 2017].
Gandhi, Rajesh T., “Has a Marker for the HIV Reservoir Been Found?” [en línea], New England Journal of Medicin, 15 de marzo 2017, <http://www.jwatch.org/na43716/2017/03/15/has-marker-hiv-reservoir-been-found> [Consulta: 15 de marzo 2017].
La Fundación Nobel, "The Nobel Prize in Physiology or Medicine 2008" [en línea], Nobelprize.org, 2008, <http://www.nobelprize.org/nobel_prizes/medicine/laureates/2008/> [Consulta: 20 de marzo 2017].
Maxmen, Amy, “Hidden HIV Reservoirs Exposed by Telltale Protein. The discovery may help doctors identify elusive infected cells in the body” [en línea], Scientific American, 16 de marzo 2017, <https://www.scientificamerican.com/article/hidden-hiv-reservoirs-exposed-by-telltale-protein/> [Consulta: 20 de marzo 2017].
Maxmen, Amy, “Hidden HIV reservoirs exposed by telltale protein. The discovery helps to identify dormant infected cells and could one day lead to a cure” [en línea], Nature, 15 de marzo 2017, <http://www.nature.com/news/hidden-hiv-reservoirs-exposed-by-telltale-protein-1.21639> [Consulta: 20 de marzo 2017].
PubMed, “Trending articles” [en línea], PubMed, <https://www.ncbi.nlm.nih.gov/pubmed/trending/> [Consulta: 20 de marzo 2017].
Riotta, Chris, “Cure For HIV, AIDS Found? Scientists Discover 'Holy Grail' Biomarker Capable Of Eliminating Virus Reservoirs” [en línea], International Business Times, 16 de marzo 2017, <http://www.ibtimes.com/cure-hiv-aids-found-scientists-discover-holy-grail-biomarker-capable-eliminating-2509716> [Consulta: 20 de marzo 2017].
Smith, Michael, “Biomarker Opens New Door in HIV Cure Research. Molecule could be first step to eradicating virus 'reservoir'” [en línea], Med Page Today, 16 de marzo 2017, <https://www.medpagetoday.com/hivaids/hivaids/63894> [Consulta: 20 de marzo 2017].
Published
Issue
Section
License
Copyright (c) 2017 Universidad Nacional Autónoma de México
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Revista Digital Universitaria es editada por la Universidad Nacional Autónoma de México se distribuye bajo una Licencia Creative Commons Atribución-NoComercial 4.0 Internacional. Basada en una obra en http://revista.unam.mx/.
